ABSTRACT
Aim: This study aimed at investigating the impact of COVID-19 lockdown on metabolic profile in bipolar disorder and schizophrenia patients at the time of COVID-19. Material(s) and Method(s): This study was completed with 190 individuals diagnosed with schizophrenia (116) and bipolar disorder (74). Waist circumference and blood pressure measurements were taken on the same date as triglyceride, glucose and HDL data in the electronic recording system of the participants. Initial assessment data are measurements within 3 months prior to the publication of the first case in Turkey. The second evaluation data, on the other hand, is the data obtained within 3 months after the date of removal or relaxation of the restrictions, which is defined as the normalization period. Result(s): A significant increase was observed in the incidence of metabolic syndrome in the participants after the COVID-19 lockdown. In addition, a significant increase in glucose, triglyceride and diastolic blood pressure values, and a significant decrease in HDL values were detected. There was no significant change in systolic blood pressure and waist circumference values. Discussion(s): It has been shown that the COVID-19 lockdown increases the incidence of metabolic syndrome in patients with schizophrenia and bipolar disorder and causes irregularities in metabolic syndrome parameters.Copyright © 2022, Derman Medical Publishing. All rights reserved.
ABSTRACT
Physical inactivity and poor dietary pattern are considered as health related challenges in ASD (ASD) which seems to be affected by Covid-19 pandemic. The purpose of this clinical trial was to investigate the effect of functional training along with online nutritional education on metabolic related biomarkers in children with ASD. 80 verified children with ASD (age=9.73 ± 1.29, weight=49.94 ± 2.08 kg, stature=146.08 ± 40 cm, BMI percentile= 64.88 ± 2.89, FM percentage+24.71 ± 1.48) were randomly divided into four groups including: (1) functional training, (2) online nutritional education, 3) training+ education and 4) control group. Pre-test was taken for metabolic related biomarkers and each experimental group received their interventions for 8 weeks. Post-test was taken at the end of 8 weeks. The results from this study, did not show significant changes for WHR (sig=0.06). Significant changes was indicated for FM (sig<0.001), TC(sig<0.001), TG (sig=0.006), HDL (sig<0.001), LDL (sig=0.001), HOMA (sig=0.04). In conclusion, functional training and online nutritional education can be considered as beneficial interventions for metabolic related biomarkers improvement in children with ASD during Covid-19 pandemic.
ABSTRACT
Background: The presence of diabetes mellitus (DM) among COVID-19 patients is associated with increased hospitalization, morbidity, and mortality. Evidence has shown that hyperglycemia potentiates SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection and plays a central role in severe COVID-19 and diabetes comorbidity. In this review, we explore the therapeutic potentials of herbal medications and natural products in the management of COVID-19 and DM comorbidity and the challenges associated with the preexisting or concurrent use of these substances. Methods: Research papers that were published from January 2016 to December 2021 were retrieved from PubMed, ScienceDirect, and Google Scholar databases. Papers reporting clinical evidence of antidiabetic activities and any available evidence of the anti-COVID-19 potential of ten selected natural products were retrieved and analyzed for discussion in this review. Results: A total of 548 papers (73 clinical trials on the antidiabetic activities of the selected natural products and 475 research and review articles on their anti-COVID-19 potential) were retrieved from the literature search for further analysis. A total of 517 articles (reviews and less relevant research papers) were excluded. A cumulative sum of thirty-one (31) research papers (20 clinical trials and 10 others) met the criteria and have been discussed in this review. Conclusion: The findings of this review suggest that phenolic compounds are the most promising phytochemicals in the management of COVID-19 and DM comorbidity. Curcumin and propolis have shown substantial evidence against COVID-19 and DM in humans and are thus, considered the best potential therapeutic options.
ABSTRACT
Background: Teens gain more weight in summer than in school, with greatest gains among teens with overweight/obesity (OWOB). Virtual learning for COVID19 social distancing may increase this risk. This study assesses change in total body fat% (TBF%) and insulin resistance (IR) during COVID19 in teens with OWOB. Methods: Teens (N = 14, Mage = 15.3, 57% male, 71% black) with OWOB who completed at least 1 fasting blood draw and DXA pre-COVID19 and were in virtual learning returned to complete another fasting blood draw and DXA (measuring TBF%). HOMA-IR was calculated via fasting glucose and insulin. Change scores were calculated for 1) pre-and during-COVID19 TBF% and 2) 2 pre-COVID19 TBF% scores. Two norm TBF% change scores were calculated from NHANES population-based data matched for age, sex, BMI% and race based on time between: 1) pre-and during-COVID19 DXAs, and 2) 2 pre-COVID19 DXAs. HOMA-IR change scores were calculated for 1) pre-and during-COVID19 and 2) 2 pre-COVID19 scores. Norm HOMA-IR change was calculated based on time between blood draws, age and BMI%. Paired t-tests compared 1) TBF% change pre-to during-COVID19 with TBF% norm change and 2) TBF% change pre-to during-COVID19 with change in 2 pre-COVID19 TBF% scores. ANCOVAs compared 1) HOMA-IR change pre-to during-COVID19 with HOMA-IR change in 2 pre-COVID19 visits controlling for BMIz and difference in time between visits and 2) HOMA-IR change from pre-to during-COVID19 with norm change in HOMA-IR controlling for sex/race. Results: TBF% change between 2 pre-COVID19 DXAs (M = .2%) and norm change (M = -.2%) were similar, but TBF% increased by ~6% more from pre-to during-COVID19 (M = 6.45%) than norm change (M = .5%,p < .01). HOMA-IR increased by ~2.5 units more from pre-to during-COVID19 (M = 3.4) than pre-COVID19 blood draws (M = 0.8;p = .03) and by ~3.5 units more than norm change (M = -.03;p = 0.01). Conclusions: TBF% and IR increased exponentially during COVID19 in teens with OWOB compared to before COVID19 and norm changes, leaving an enduring effect on health.